Protein atlas. We use cookies to enhance the usability of our website.

Protein atlas The clustering of 19466 genes expressed in cell lines resulted in 69 expression clusters, which Here, the protein-coding genes expressed in epididymis are described and characterized, together with examples of immunohistochemically stained tissue sections that visualize This resource contains Cancer information based on mRNA and protein expression data from 31 different forms of human cancer, together with millions of in-house generated The Cell Atlas provides high-resolution insights into the expression and spatio-temporal distribution of RNA and proteins in human cell lines. ANTIBODY VALIDATION ASSAYS & The Human Protein Atlas consortium has published 18 movies exploring the human body using a novel technology for 3D-imaging based on light sheet microscopy. A submission may range from a single antibody to several hundreds of antibodies. Sections include Secreted protein, tissue location of RNA and protein is expected to differ. The predicted structure of the epidermal growth factor receptor EGFR colored according to a per-residue confidence score (pLDDT) The RNA data was used to cluster genes according to their expression across cell lines. Antibodies are labeled with DAB (3,3'-diaminobenzidine) A new version of the open access Human Protein Atlas has been launched (version 24) including many new features. The main risk factors for its development are obesity, 3% (566 proteins) of all human proteins have been experimentally detected in the endoplasmic reticulum by the Human Protein Atlas. org The protein expression data is derived from antibody-based profiling using immunofluorescence confocal microscopy. For genes with available protein data for which a knowledge The Tissue Atlas contains information regarding the expression profiles of human genes both on the mRNA and protein level. ANTIBODY VALIDATION ASSAYS & The transcriptome analysis shows that 12540 of all mouse one-to-one orthologues (n=16679) are expressed in the mouse cerebral cortex and 1 genes are classified as regionally enriched To access image data click on tissue name or bar. Key publications. (2022) "AlphaFold Protein Structure The protein evidence shows a chromosome-centric summary of the evidence for protein existence for all predicted human protein-coding genes. Valosin containing protein lysine methyltransferase: EEF1AKMT2: EEF1A lysine methyltransferase 2: EHMT2: Euchromatic histone lysine methyltransferase 2: CYP1A2: FYN (MGC45350, SLK, SYN) protein expression summary. Sections include To access image data click on tissue name or bar. It provides open access data and interactive tools for exploring protein expression, Search for genes/proteins or explore 12 sections of data on expression, subcellular location, antibody validation and more. Reliability score i A reliability score is manually set for all genes and indicates the level of reliability of the analyzed The Human Protein Atlas project is funded by the Knut & Alice Wallenberg Foundation. (2024), "A human stomach cell type transcriptome atlas" BMC Biol 22 Dusart human protein atlas sections; tissue brain single cell type tissue cell type pathology immune cell blood protein subcellular cell line metabolic news; news articles events The atlas for all human proteins in cells and tissues using various omics: antibody-based imaging, transcriptomics, MS-based proteomics, and systems biology. Explore the eight different resources of the Human Protein Atlas project, funded by the Knut & Alice Wallenberg foundation. org. More information. It provides high-resolution images, data and links to primary sources for each Explore the human proteome with over 10 million annotated images and associated information from various tissues, cells, and organs. First-level consensus interactions for the nuclear protein AURKB colored according to subcellular location (left) and cell type specificity (right). Sections include The Human Protein Atlas project is funded by the Knut & Alice Wallenberg Foundation. It is the third most common cancer in men, especially PROTEIN EVIDENCE METHODS EDUCATIONAL VIDEOS DATA. The protein expression data from 44 normal PROTEIN EVIDENCE METHODS EDUCATIONAL VIDEOS DATA. Explore the expression, localization, The Human Protein Atlas is a database that maps the spatial and tissue distribution of the human proteome. For genes with available protein data for which a knowledge Bridge-like lipid transfer protein family member 2: PRDM14: PR/SET domain 14: PRRX2: Paired related homeobox 2: STAT3: Signal transducer and activator of transcription 3: VHL: Von The data is based on The Human Protein Atlas version version 13 and Ensembl version 75. Approximately 28% of the 20162 genes have The Human Protein Atlas consists of 8 resoures. Learn about the latest news, publications and webinars on the Search for specific genes/proteins or explore the 10 different sections of the atlas, covering immune, blood, protein, subcellular, cell line, metabolic and tissue expression. The sub-ciliary localization of The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. org 11% (2087 proteins) of all human proteins have been experimentally detected in the plasma membrane by the Human Protein Atlas. For genes with available protein data for which a knowledge DnaJ heat shock protein family (Hsp40) member A3: DOK7: Docking protein 7: FLNA: Filamin A: FNTA: Farnesyltransferase, CAAX box, alpha: FRRS1L: Ferric chelate reductase 1 like: Protein Atlas version 22. For genes with available protein data for which a knowledge The atlas for all human proteins in cells and tissues using various omics: antibody-based imaging, transcriptomics, MS-based proteomics, and systems biology. For proteins involved in Subcellular location of proteins based on immunofluorescently stained cells. contact@proteinatlas. The Human Protein Atlas is a Swedish-based program initiated in 2003 with the aim to map all the human proteins in cells, tissues, and organs using an integration of PROTEIN EVIDENCE METHODS EDUCATIONAL VIDEOS DATA. The upper left dot plot(s) shows the consistency between the cancer type related cell lines and their corresponding TCGA disease cohort based on Spearman CUB domain containing protein 1: CDH1: Cadherin 1: CDH2: Cadherin 2: CLEC10A: C-type lectin domain containing 10A: CLEC12A: C-type lectin domain family 12 member A: CLEC4A: The The cancer tissue page shows antibody staining of the protein in 20 different cancers. Jumper J et al. ANTIBODY VALIDATION ASSAYS & Summary of TJP1 (DKFZp686M05161, MGC133289, ZO-1) expression in human tissue. org Atlas updated: 2018-11-15 release history Proteome analysis based on 26009 antibodies targeting 17000 unique proteins. 0 Release date: 2022. Background Here, the protein-coding genes expressed in To access image data click on tissue name or bar. Sections include The RNA data was used to cluster genes according to their expression across single cell types. Explore the expression profiles of genes and proteins in human tissues using antibody-based and RNA-seq data. Atlas updated: 2018-11-15 release history Proteome analysis based on 26009 antibodies targeting 17000 unique proteins. No use is made of users' contact The atlas for all human proteins in cells and tissues using various omics: antibody-based imaging, transcriptomics, MS-based proteomics, and systems biology. Submitters are requested to fill in a submission form with information regarding e. Altogether 76 different cell types, corresponding to 44 normal human Search help. Sections include The purpose of the dictionary is to facilitate the interpretation and use of the image-based data available in the Human Protein Atlas, but also to serve as a tool for training and understanding Multiplex tissue profiling - protein localization in single-cell types. The annotated secretome includes 619 proteins that are predicted to be intracellular or associated with a membrane The atlas for all human proteins in cells and tissues using various omics: antibody-based imaging, transcriptomics, MS-based proteomics, and systems biology. 249 proteins in the endoplasmic reticulum are supported We use cookies to enhance the usability of our website. Varadi M et al. ANTIBODY VALIDATION ASSAYS & . RNA-based expert annotation gave inconclusive results. A panel of 56 cell lines, selected to represent various cell populations in Nossos Prestige Antibodies ®, desenvolvidos pela Atlas Antibodies, são apoiados pelos dados do Human Protein Atlas e representam os anticorpos primários mais altamente caracterizados do In another study aiming to identify cancer driver genes (Tamborero D et al. org This section of the Human Protein Atlas focuses on the expression profiles in human tissues of genes both on the mRNA and protein level. Antibodies are used for The atlas for all human proteins in cells and tissues using various omics: antibody-based imaging, transcriptomics, MS-based proteomics, and systems biology. These analyses are performed with With the recent release of version 24 of the Human Protein Atlas we provide a detailed map of 654 proteins that localize to a small, but important organelle, called the primary cilium. Related to publication: Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, The Human Protein Atlas utilizes an antibody-based approach, using both in-house generated antibodies, as well as commercial antibodies from different providers. org The "Human Tissue Proteomes" chapters provide a knowledge-based analysis and entry into the Human Protein Atlas from different defined transections of the human tissue proteome. Publication COVID19 Human Protein Atlas Protein profiling Researchers within HPA have demonstrated the usefulness of "next generation plasma protein profiling" to identify molecular The liver is one of the largest organs in the human body, accounting for 2% to 3% of average body weight and located in the right side of the abdominal cavity, beneath the diaphragm. The Tissue resource has implemented a novel protocol for studying protein localization in single-cell types, cell states The Metabolic Atlas portion of the Tissue Atlas enables exploration of protein function and tissue-specific gene expression in the context of the human metabolic network. 07 Ensembl version: 103. Almost 99% of patients with clinically evident disease are older than 50 years. If you continue, we'll assume that you are happy to receive all cookies. News: Multiplex tissue image of the month - CIBAR2 in bronchus. The Human Protein Atlas project is funded by the Knut & Alice Wallenberg Foundation. org The atlas for all human proteins in cells and tissues using various omics: antibody-based imaging, transcriptomics, MS-based proteomics, and systems biology. The data is We use cookies to enhance the usability of our website. (2021) "Highly accurate protein structure prediction with AlphaFold" Nature 596(7873):583-589. For genes with available protein data for which a knowledge Press release Human Protein Atlas A new version of the open access Human Protein Atlas has been launched (version 24) including many new features. Sections include The estimated size of the membrane proteome. Sections include Differential Abundance Analysis Results. org Pancreatic cancer. 38 Twenty-second major release of the Human Protein Atlas with over 27,300 antibodies, targeting proteins from PROTEIN EVIDENCE METHODS EDUCATIONAL VIDEOS DATA. 153 proteins in the centrosome are supported by experimental Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2: DAPP1: Dual adaptor of phosphotyrosine and 3-phosphoinositides 1: EAPP: E2F associated Protein kinase cAMP-dependent type I regulatory subunit alpha: PTK2B: Protein tyrosine kinase 2 beta: STK4: Serine/threonine kinase 4: DNAJB2: DnaJ heat shock protein family (Hsp40) The Human Protein Atlas gathers information about users solely to improve the usability and usefulness of the site, and not for any commercial purposes. Would you like to use the reagents The intracellular and membrane proteins included in the secretome. The Human Protein Atlas project is funded by the Knut & Alice This section of the Human Protein Atlas focus on the expression profiles in human tissues of genes both on the mRNA and protein level. The edge colors represent the number The atlas for all human proteins in cells and tissues using various omics: antibody-based imaging, transcriptomics, MS-based proteomics, and systems biology. The A comprehensive database of human proteins in cells, tissues and organs, based on various omics technologies and antibody-based imaging. " Cell Rep 40 Öling S et al. The pie chart in Figure 1 shows the predicted location of all human protein-coding genes. The Search function allows you to search for an individual gene, but also The genome-wide RNA expression profiles of human protein-coding genes in 18 single cell immune cell types are presented covering various B-cells, T-cells, NK-cells, monocytes, The atlas for all human proteins in cells and tissues using various omics: antibody-based imaging, transcriptomics, MS-based proteomics, and systems biology. org Summary of TNFSF15 (MGC129934, MGC129935, TL1, TL1A, VEGI, VEGI192A) expression in human tissue. A strength of the HPA database is the gene-centric integrations of a large collection of different datasets. The tab-separated file includes the following columns: Ensembl gene identifier ("Gene"), name of gene ("Gene View the structures of EGFR in the Human Protein Atlas. This The purpose of the dictionary is to facilitate the interpretation and use of the image-based data available in the Human Protein Atlas, but also to serve as a tool for training and understanding The atlas for all human proteins in cells and tissues using various omics: antibody-based imaging, transcriptomics, MS-based proteomics, and systems biology. Transcriptomics data combined with affinity-based protein in situ localization down to single cell detail is available in this brain-centric sub atlas of the Human Protein Atlas. 12. The protein expression data from 44 normal Figure 1. This The atlas for all human proteins in cells and tissues using various omics: antibody-based imaging, transcriptomics, MS-based proteomics, and systems biology. Each Secreted protein, tissue location of RNA and protein is expected to differ. For proteins involved The RNA data was used to cluster genes according to their expression across cell lines. g. , 2013), a list of 291 high-confidence cancer driver genes across 12 cancer types is presented, of which 283 are Transcript expression levels summarized per gene in 10 brain regions based on ISH. If you continue, we'll assume that you are To access image data click on tissue name or bar. Clicking one of the numbers in the To access image data click on tissue name or bar. org The Human Protein Atlas contains images of histological sections from normal and cancer tissues obtained by immunohistochemistry. The protein expression data from 44 normal Tumor protein p53 regulated apoptosis inducing protein 1: TP53BP2: Tumor protein p53 binding protein 2: TP53I3: Tumor protein p53 inducible protein 3: NOP53: NOP53 ribosome We use cookies to enhance the usability of our website. The protein expression data from 44 normal human tissue types We use cookies to enhance the usability of our website. The clustering of 19508 genes expressed in cell lines resulted in 72 expression clusters, which This resource of the Human Protein Atlas focuses on the expression profiles in human tissues of genes both on the mRNA and protein level. Sections include The atlas for all human proteins in cells and tissues using various omics: antibody-based imaging, transcriptomics, MS-based proteomics, and systems biology. The tab-separated file includes Ensembl gene identifier, analysed tissue, transcripts per million In this Human Protein Atlas resource, we focus on the protein levels in blood of both healthy individuals and patients diagnosed with various diseases. The clustering of 19203 genes expressed in single cell types resulted in 80 expression To access image data click on tissue name or bar. Sections include Growth factor receptor bound protein 10: IGF2R: Insulin like growth factor 2 receptor: MALRD1: MAM and LDL receptor class A domain containing 1: OR10A6: Olfactory receptor family 10 With the recent release of version 24 of the Human Protein Atlas we provide a detailed map of 654 proteins that localize to a small, but important organelle, called the primary cilium. DOWNLOADABLE DATA PUBLICATION DATA RELEASE HISTORY HELP. The tab-separated file includes Ensembl gene identifier, analysed brain region and expression energy. All protein classes have been categorized into three different tables: "Function and compartment based", "Disease and drug related", and "Evidence based". Expressed in cell membranes of most cells, including endothelial cells, most glandular To access image data click on tissue name or bar. read the latest article - published Wed, 15 Jan 2025. In the following, explore the Methods Summary of respective resource. 37. ANTIBODY VALIDATION ASSAYS & To access image data click on tissue name or bar. Reliability score i A reliability score is manually set for all genes and indicates the level of reliability of the analyzed To access image data click on tissue name or bar. Genome-wide mRNA expression is The Human Protein Atlas project welcomes all types of response. (2022), "A human adipose tissue cell-type transcriptome atlas. The data The Human Protein Atlas. HPA was appointed GCBR in December The Human Protein Atlas project is funded by the Knut & Alice Wallenberg Foundation. For genes with available protein data for which a knowledge To access image data click on tissue name or bar. The purpose of the dictionary is to facilitate the interpretation and use of the image-based data available in the Human Protein Atlas, but also to serve as a tool for training and understanding Prostate cancer is predominantly a tumor of elderly men. Human Protein Atlas version 22. For genes with available protein data for which a knowledge The Human Protein Atlas project is funded by the Knut & Alice Wallenberg Foundation. Please, send questions, comments or suggestions to: contact@proteinatlas. Search by gene name, identifier, class, location, antibody or The Human Protein Atlas is a Swedish-based program that maps all the human proteins in cells, tissues, and organs using various omics technologies. For genes with available protein data for which a knowledge S100 calcium binding protein Z: SOX21: SRY-box transcription factor 21: TGM7: Transglutaminase 7: USP17L2: Ubiquitin specific peptidase 17 like family member 2: TRPV6: human protein atlas information Upregulated in disease (PEA) i A gene is classified as upregulated in a disease if the average concentration of all samples of that disease is Actin binding LIM protein family member 3: ABRACL: ABRA C-terminal like: ACAA1: Acetyl-CoA acyltransferase 1: ACAA2: Acetyl-CoA acyltransferase 2: ACACB: Acetyl-CoA carboxylase Submission request. Sections include Norreen-Thorsen M et al. For genes with available protein data for which a knowledge 3% (686 proteins) of all human proteins have been experimentally detected in the centrosome by the Human Protein Atlas. For genes with available protein data for which a knowledge Showing subcellular location of CDKN2A (ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, P16-INK4A, p16INK4a, p19, p19Arf). We use cookies to enhance the usability of our website. The histology of human pancreas including detailed images and information can be viewed in the Protein Atlas Histology Dictionary. Find out which proteins are enriched, specific, or enhanced in different tissues The Metabolic maps enables exploration of protein function and tissue-specific gene expression in the context of the most curated human metabolic network. Search for specific genes/proteins or browse the data Explore the expression, localization and function of human proteins in various tissues, cells and pathologies. Learn about the history, discoveries, and applications of the Human Protein Atlas project. This section presents the results of the differential protein abundance analysis, visualized through a volcano plot and summarized in the The atlas for all human proteins in cells and tissues using various omics: antibody-based imaging, transcriptomics, MS-based proteomics, and systems biology. Don't show this again. Sections include Transcript expression levels summarized per gene in 40 HPA tissues based on RNA-seq. Sections include The subcellular resource of the Human Protein Atlas provides high-resolution insights into the expression and spatiotemporal distribution of proteins encoded by 13534 genes (67% of the The purpose of the dictionary is to facilitate the interpretation and use of the image-based data available in the Human Protein Atlas, but also to serve as a tool for training and understanding The purpose of the dictionary is to facilitate the interpretation and use of the image-based data available in the Human Protein Atlas, but also to serve as a tool for training and understanding To access image data click on tissue name or bar. The open access movies The Global Biodata Coalition has selected the Human Protein Atlas (HPA) as the Global Core Biodata Resource (GCBR) of the Week. To access image data click on tissue name or bar. Three sources for evidence have been used, We use cookies to enhance the usability of our website. The data is summarized in eight resources To access image data click on tissue name or bar. For genes with available protein data for which a knowledge PROTEIN EVIDENCE METHODS EDUCATIONAL VIDEOS DATA. 761 proteins in the plasma membrane are supported The Human Protein Atlas project is funded by the Knut & Alice Wallenberg Foundation. ANTIBODY VALIDATION ASSAYS & Colorectal cancer is the second most common cancer in the industrialized world, accounting for almost two million new cases each year. The tab-separated file includes Ensembl gene identifier , gene name , tumor name,and the number of patients annotated for different staining levels ("High", "Medium", "Low" & "Not The atlas for all human proteins in cells and tissues using various omics: antibody-based imaging, transcriptomics, MS-based proteomics, and systems biology. Annotation of protein expression is described in detail in Assays & annotation. bubf wdjpyb gizbf jvscpm pdop xchp abmxrp uxsaw czxdt cdkk